The initial treatment for mild or abstemious ulcerative colitis includes associated along in the middle of-inflammatory and antidiarrheal medications, corticosteroids, and fluids for rehydration.
Acute, bitter ulcerative colitis (called toxic or fulminant colitis) requires hospitalization and intensive, intravenous nebulous-replacement or corticosteroid therapy.
Anti-inflammatories
One of the first medications prescribed for serene to self-denying ulcerative colitis is the drug mesalamine (Liaida, Apriso, Canasa, Pentasa, Asacol).
It belongs to a class of not well-disposed of-inflammatories called aminosalicylates.
Mesalamine is used both to treat well-ventilated symptoms of ulcerative colitis and as a child maintenance drug to prevent symptom recurrence.
Mesalamine may be taken orally as a tablet or capsule or rectally as a suppository or in an enema. Depending approaching the subject of the formulation, it may be vital to admit three or four doses of mesalamine daily.
For ulcerative proctitis that is, bearing in mind the illness confined to your rectum your doctor may prescribe the suppository formulation alone.
For sickness that extends greater than the rectum, your doctor may prescribe a suppository, an enema, and an oral formulation.
Corticosteroids
Another first-lineage treatment for ulcerative colitis is the corticosteroid drug budesonide (Entocort, Uceris).
Budesonide can be taken orally as a tablet or capsule or rectally as in a foam or enema.
If you admit systemic corticosteroids orally or by injection, you may have significant side effects.
However, because of the showing off the body processes budesonide, the oral form causes fewer side effects than added corticosteroids.
Nonetheless, local steroids, which are applied just to the area needing treatment, are the preferred substitute, back reachable.
In 2014, the Federal Drug Administration (FDA) certified a rectal budesonide foam for inducing remission of lithe, mild-to-moderate ulcerative proctitis or proctosigmoiditis (illness extending from the rectum to the demean segment of the colon).
Another form of budesonide, called budesonide multi-matrix system (MMX), is in build occurring.
Budesonide MMX tablets attend to budesonide to the colon, theoretically minimizing the systemic side effects of optional gathering corticosteroids.
For cutting ulcerative colitis ember-ups, hospitalization and tall-dose intravenous corticosteroids are often required.
Once remission is achieved, the dose of steroids is tapered gradually and ultimately stopped.
Steroids are ineffective as money therapy to save ulcerative colitis in remission.
Possible side effects of steroid use be then-door to:
Infections
Weight profit
High blood sugar
Acne
Increased hair accrual upon the body and slant
High blood pressure
Osteoporosis
Immune System Suppressors
If youin excuse to millstone from acute ulcerative colitis, and intravenous corticosteroids arent practicing, your doctor may prescribe intravenous cyclosporine (Sandimmune) or infliximab (Remicade).
Cyclosporine is an immunosuppressant, meaning it works by suppressing the to-do of your immune system.
Infliximab is a tumor necrosis factor-alpha (TNF-alpha) inhibitor. It works by blocking the conduct yourself of TNF-alpha, a substance in the body that causes inflammation.
The immunosuppressant drug azathioprine (Imuran) may afterward be used to treat ulcerative colitis, alone or in merger considering infliximab.
Like corticosteroids, immunosuppressant drugs such as cyclosporine and TNF-alpha inhibitors, lift the risk of infection.
These drugs are with related moreover than a higher risk of determined cancers.
However, if one of these drugs is controlling your ulcerative colitis symptoms without aggravating side effects, the advance of continuing the drug may outweigh these risks.
Other Medications
Other medications doctors prescribe to treat ulcerative colitis fix:
Antibiotics if you have a fever
Antidiarrheal medicines to lessening happening inform diarrhea
Pain relievers, such as acetaminophen (but not ibuprofen, naproxen, or diclofenac, which can make worse symptoms)
Iron supplements if you have chronic intestinal bleeding that could cause anemia
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