People who injected Saxenda (liraglutide) all day for a year at a loose call off an average of 18.5 pounds, compared related to an average of 6 pounds for those taking a placebo, researchers found.
Saxenda can demean weight, accumulation going on cardiovascular risk factors and titivate vibes of simulation, said gain learned Dr. F. Xavier Pi-Sunyer, professor of medicine at Columbia University Medical Center in New York City.
It can plus shorten the pro to type 2 diabetes from prediabetes, he said.
In a belittle-dose footnote called Victoza, liraglutide is manager for diabetes treatment.
For the breakdown, funded by the maker of Saxenda, Novo Nordisk, researchers recruited on top of 3,700 overweight or obese people without diabetes . Participants were assigned to daily injections of Saxenda or placebo for 56 weeks. Both groups along with usual lifestyle counseling. More than half had prediabetes.
Sixty-three percent of patients taking Saxenda loose at least 5 percent of their initial body weight, and one-third aimless in addition to than more 10 percent of body weight, the researchers found. Among those receiving placebo, 27 percent free 5 percent of their body weight, and one in 10 aimless greater than 10 percent of their body weight.
Losing 5 percent of body weight 14 pounds for someone at 280 can have a significant pure effect on the order of the risk for diabetes and heart illness, Pi-Sunyer said.
In the United States, behind more two-thirds of adults are overweight or obese, according to a recent psychotherapy in JAMA Internal Medicine.
This medication adds to the options physicians will have in helping overweight and obese patients lose weight and save it off, Pi-Sunyer said.
The testing was published July 2 in the New England Journal of Medicine.
Other drugs endorsed for weight loss in the United States optional add-on Orlistat (Xenical), lorcaserin (Belviq), phentermine-topiramate (Qsymia) and naltrexone-bupropion (Contrave). But many users complain of side effects.
The most common side effects also Saxenda were mild or self-denying nausea and diarrhea. Serious side effects occurred in 6.2 percent of patients taking Saxenda and in 5 percent of those receiving the placebo, the researchers fable.
However, the drug is expensive, said Dr. Joel Zonszein, director of the clinical diabetes middle at Montefiore Medical Center in New York City.
Although covered by most of the insurance plans and Medicare, it has a tall co-pay of $20 to $100, as it is not generic, Zonszein said. The price in the U.S. is between $1,000 and $1,800 for a three-month supply.
Dr. Elias Siraj, director of the diabetes program at Temple University School of Medicine and Hospital in Philadelphia, said its important to recall that obesity is a lifestyle condition.
We should not lose sight of the compulsion to complete used to lifestyle diet and exercise, he said. Medications, too, can be yielding.
The unanswered ask not quite Saxenda is whether people can bond their weight loss anew time, especially along surrounded by the medication is discontinued, said Siraj, co-author of an editorial accompanying the testing.
Because the drug is injectable and expensive, Siraj doesnt think its for everybody. But for some patients I think it is going to be a significant tool, but we have to wait for longer studies, he said.
We are dealing like an obesity epidemic and it hasnt been easy to lecture to obesity, he said. We obsession a lot of tools. This medication, hopefully, will be one of the tools.
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