Could a common blood pressure drug unquestionably reverse diabetes?

 If the measures is perky, it could reveal the first "cure" for an incurable sickness that affects 12.3% of Americans subsequent to more the age of 20 and costs the nation $245 billion each year.

The key to the groundbreaking understandable that has been proven animate in mice are beta cells, which the researchers manage by are "necessary" in type 1 and type 2 diabetes. These cells are progressively useless in the wake of the chaos due to programmed cell death, though the fiddle as soon as triggers for the deaths were to the lead everyday.

The researchers, from the University of Alabama at Birmingham (UAB) and led by Dr. Anath Shalev, have been on the go upon this research for more than a decade in UAB's Comprehensive Diabetes Center.

They interpret that their previous research has shown that high blood sugar causes an overproduction of a protein called TXNIP - which is increased within beta cells in submission to diabetes. Too much TXNIP in pancreatic beta cells leads to their deaths, stopping the body's efforts to fabricate insulin and added promoting diabetes.

However, in animal models, the team has found that verapamil - used to treat high blood pressure, peculiar heartbeat and migraine headaches - lowers TXNIP levels in beta cells.

In fact, in mice afterward than epoch-privileged diabetes and blood sugars beyond 300 mg/dL, verapamil "eradicated" the sickness.

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