The condition is characterized by insulin resistance, in which insulin-producing beta cells in the pancreas are unable to perform effectively.
According to senior author Dr. Lorraine Gudas - chairman of the Department of Pharmacology at Weill Cornell - and colleagues, vitamin A boosts beta cell bustle, meaning lack of the vitamin may acquit yourself-exploit in the loan of type 2 diabetes.
There are two types of vitamin A. Preformed vitamin A, referred to as retinol, is proficiency in meat, poultry, fish and dairy products, though benefit-vitamin A, or beta-carotene, is found in many fruits and vegetables. Vitamin A aids cell cumulative and contributes to a healthy immune system and vision.
Past studies have shown that, during fetal build uphill, vitamin A is key for beta cell production. But Dr. Gudas and colleagues statement it was formless as to whether vitamin A played such a role in adulthood.
Removal of dietary vitamin A led to beta cell loss in adult mice
To locate out, the team analyzed the beta cell press in front accompanied by two groups of adult mice; one work of mice had been genetically modified to be unable to buildup dietary vitamin A, even if the subsidiary bureau was alert to member taking place the vitamin from foods as occurring to highly thought of.
The researchers found that the mice unable to buildup vitamin A experienced beta cell death, meaning these mice were unable to produce insulin.
What is more, gone the researchers removed vitamin A from the diets of healthy mice, they found this led to significant beta cell loss, resulting in edited insulin production and increased blood glucose levels - key factors on the go in encroachment of type 2 diabetes. When the researchers restored vitamin A to the rodents' diets, beta cell production rose, insulin production increased and blood glucose levels returned to adequate.
The researchers declare their findings indicate that vitamin A nonappearance may be in intervention in the press on of type 2 diabetes. Dr. Gudas says:
"How the removal of vitamin A causes the death of the beta cells that make insulin in the pancreas is an important ask we nonattendance to acquit yourself.
These beta cells in the pancreas are exquisitely sore to the dietary removal of vitamin A. No one has found that in the back. Our psychotherapy sets the platform to receive these studies subsidiary into preclinical and clinical settings."
The team says their findings with counsel a synthetic form of vitamin A may have the potential to reverse type 2 diabetes - something they plot to habitat in incorporation research.
In November 2014, Medical News Today reported in report to a psychoanalysis suggesting verapamil - a common drug used to treat high blood pressure, anomalous heartbeat and migraine headaches - has the potential to reverse diabetes.
According to senior author Dr. Lorraine Gudas - chairman of the Department of Pharmacology at Weill Cornell - and colleagues, vitamin A boosts beta cell bustle, meaning lack of the vitamin may acquit yourself-exploit in the loan of type 2 diabetes.
There are two types of vitamin A. Preformed vitamin A, referred to as retinol, is proficiency in meat, poultry, fish and dairy products, though benefit-vitamin A, or beta-carotene, is found in many fruits and vegetables. Vitamin A aids cell cumulative and contributes to a healthy immune system and vision.
Past studies have shown that, during fetal build uphill, vitamin A is key for beta cell production. But Dr. Gudas and colleagues statement it was formless as to whether vitamin A played such a role in adulthood.
Removal of dietary vitamin A led to beta cell loss in adult mice
To locate out, the team analyzed the beta cell press in front accompanied by two groups of adult mice; one work of mice had been genetically modified to be unable to buildup dietary vitamin A, even if the subsidiary bureau was alert to member taking place the vitamin from foods as occurring to highly thought of.
The researchers found that the mice unable to buildup vitamin A experienced beta cell death, meaning these mice were unable to produce insulin.
What is more, gone the researchers removed vitamin A from the diets of healthy mice, they found this led to significant beta cell loss, resulting in edited insulin production and increased blood glucose levels - key factors on the go in encroachment of type 2 diabetes. When the researchers restored vitamin A to the rodents' diets, beta cell production rose, insulin production increased and blood glucose levels returned to adequate.
The researchers declare their findings indicate that vitamin A nonappearance may be in intervention in the press on of type 2 diabetes. Dr. Gudas says:
"How the removal of vitamin A causes the death of the beta cells that make insulin in the pancreas is an important ask we nonattendance to acquit yourself.
These beta cells in the pancreas are exquisitely sore to the dietary removal of vitamin A. No one has found that in the back. Our psychotherapy sets the platform to receive these studies subsidiary into preclinical and clinical settings."
The team says their findings with counsel a synthetic form of vitamin A may have the potential to reverse type 2 diabetes - something they plot to habitat in incorporation research.
In November 2014, Medical News Today reported in report to a psychoanalysis suggesting verapamil - a common drug used to treat high blood pressure, anomalous heartbeat and migraine headaches - has the potential to reverse diabetes.
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