The Latest in Bladder Cancer Research

Incidence and Mortality
While urinary bladder cancer incidence rates are much well along in whites than in African Americans, mortality rates are unaided slightly difficult, due in large portion to the innovative stage at diagnosis together in the company of African Americans. Incidence and mortality rates for Hispanics, American Indians/Alaska Natives, and Asians/Pacific Islanders are lower than those for whites and African Americans. Incidence and mortality rates have tainted highly tiny for most racial and ethnic groups following again the p.s. 20 years, gone the exception of African Americans, for whom mortality has been decreasing. Men are about four time more likely than women to be diagnosed gone bladder cancer. Since 1998, mortality rates have been stable in men and slowly declining in women.

Smoking is the most important risk factor for bladder cancer. Other risk factors tote occurring expression to chemicals in the workplace (rubber, paint, hairdressing chemicals), taking determined chemotherapy drugs, and arsenic contamination in drinking water. There is no enough or routine screening exam for bladder cancer, but two tests, cystoscopy and urine cytology, may be used in patients who have back had bladder cancer. Standard treatments for bladder cancer are surgery, radiation therapy, chemotherapy, and biological therapy.

It is estimated that almost $4.0 billion is spent in the United States each year on the order of speaking bladder cancer treatment.

Examples of NCI Activities Relevant to Bladder Cancer
The Prostate and Urologic Cancer Research Group conducts and supports clinical trials, biomarker discovery, and technology fee for the prevention and yet to be detection of prostate and bladder cancers.
The Mouse Models of Human Cancers Consortium (MMHCC) has developed several murine cancer models, including those relevant to the urinary system, which are to hand to the research community.
The phase I/II proceedings Paclitaxel and Radiation Therapy With or Without Trastuzumab in Treating Patients Who Have Undergone Surgery for Bladder Cancer is studying the side effects and efficacy of a mixture of the drug paclitaxel (Taxol) and daily radiation therapy in patients as soon as invasive bladder cancer. Patients whose tumors are HER2 pardon along with will be treated gone the monoclonal antibody trastuzumab (Herceptin).
Investigators participating in the International Consortium of Bladder Cancer coordinate research procedures and pool data across ongoing and completed bladder cancer epidemiology studies.
Investigators in The Cancer Genome Atlas (TCGA) revealed a metabolic shift that was similar to tumor stage and aggressiveness in a common kidney cancer, sure cell renal cell carcinoma. [PubMed Abstract]
One bladder-cancer-specific Specialized Program of Research Excellence (SPORE) is studying the forward detection of bladder cancer, choice therapeutic strategies, and markers to predict bladder cancer recurrence.
Selected Advances in Bladder Cancer Research
A genetic variant that is linked once increased bladder tumor outing of prostate stem cell antigen generates a protein that is a potential therapeutic object. Published December 2012. [PubMed Abstract]
Loss of the SPARC protein promotes bladder cancer growth uphill and metastasis. Published January 2013. [PubMed Abstract]
Intravesical delivery of a pull of chemotherapy drugs may prevent localized bladder cancer from progressing to metastatic sickness. Published February 2013. [PubMed Abstract]
Former smokers, even those in imitation of a self-denying records of smoking, have an increased risk of bladder cancer for many years after quitting smoking. Published March 2013. [PubMed Abstract]
See this PubMed list of agreed easy to do to full-text journal articles around NCI-supported research relevant to bladder cancer. You can furthermore search PubMed for subsidiary scientific articles or to firm a search tutorial.
Trends in NCI Funding for Bladder Cancer Research
The National Cancer Institute's (NCI) investment in bladder cancer research decreased slightly from $24.1 million in fiscal year (FY) 2008 to $23.4 million in FY 2012. In garnish to this funding, NCI supported $3.1 million in bladder cancer research in FY 2009 and FY 2010 using funding from the American Recovery and Reinvestment Act (ARRA).

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