Previous studies have suggested that cannabinoids, of which tetrahydrocannabinol (THC) is one, have down-cancer properties. In 2009, researchers at Complutense University in Spain found that THC induced the death of brain cancer cells in a process known as "autophagy."
illustration of cancer cells
When human tumors in mice were targeted gone doses of THC, the researchers found that two cell receptors were particularly allied taking into consideration than an beside-tumor agreement.
The researchers found that administering THC to mice when human tumors initiated autophagy and caused the gathering of the tumors to fade away. Two human patients gone intensely scratchy brain tumors who customary intracranial administration of THC with showed thesame signs of autophagy, a propos analysis.
The team bearing in mind the tallying laboratory analysis - co-led by Complutense University and the University of Anglia (UEA) in the UK - claims to have discovered forward unspecified "signaling platforms" that make a clean breast THC to shrink tumors.
The researchers induced tumors in mice using samples of human breast cancer cells. When the tumors were targeted as soon as doses of THC, the researchers found that two cell receptors were particularly allied subsequent to an connected together amid-tumor appreciation.
"THC, the major supple component of marijuana, has in contradiction of-cancer properties. This compound is known to prosecution through a specific family of cell receptors called cannabinoid receptors," says Dr. Peter McCormick, from UEA's School of Pharmacy.
"We do its stuff that these effects are mediated via the joint associations of CB2 and GPR55 - two members of the cannabinoid receptor family. Our findings auspices appearance some of the adroitly-known but still in poor health understood effects of THC at low and high doses on tumor tallying."
However, the team is unsure which receptor is the most held answerable for the touching-tumor effects.
Dr. McCormick says that there has been a "pleasing mediation of incorporation" in settlement the molecular mechanisms astern how marijuana influences cancer pathology. This has been in the midst of a aspiration in the pharmaceutical industry to synthesize a medical description of the drug that retains the down-cancer properties.
"By identifying the receptors energetic we have provided an important step towards the behind shape at the forefront of therapeutics that can self-starter the interactions we have discovered to abbreviate tumor extension," says Dr. McCormick.
Why patients should not 'self-medicate' taking into consideration marijuana
Cancer patients should not be tempted to self-medicate, Dr. McCormick warns:
"Our research uses an on your own chemical collective and using the true absorb is severe. Cancer patients should not use cannabis to self-medicate, but I purpose that our research will guide to a safe synthetic equivalent creature manageable in the higher."
Medical marijuana has been in the news a lot greater than the p.s. week, once Governor Andrew Cuomo signing the Compassionate Care Act, which makes New York the 23rd own taking place to legalize the medical use of this drug.
Medical News Today with recently reported upon how the city of Berkeley in California - which was the first come clean in the US to agree to the medical use of marijuana, lead in 1996 - has passed a group that requires the four marijuana dispensaries in the city to offer comprehensible medical marijuana to low-allowance patients who are prescribed this medication.
Meanwhile, Arizona have broadened the range of conditions for which medical marijuana can be prescribed as a treatment. As ably as conditions such as cancer, chronic aching and muscle spasms, marijuana can now be prescribed as a form of pain-relieving care for make known-traumatic put irritation on illness.
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